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The complications associated with bilirubin include hepatic encephalopathy, auditory dysfunction, skeletal muscle damage, extrapyramidal symptoms like athetosis and chorea, visual abnormalities including gaze palsies, abnormalities in dentition, extrapyramidal symptoms like athetosis and chorea, visual abnormalities including gaze palsies, abnormalities in dentition, etc

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10.1152/physrev.00034.2023 77 KrishnamurthyH

However, they found that in knock-in mice expressing MOR mutant S375A substitution, proposed by these authors to be the primary site of morphine-induced phosphorylation of MOR responsible for desensitization (Schulz et al., 2004), morphine tolerance was not affected (Grecksch et al., 2011)