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Pyridoxine Induces Glutathione Synthesis via PKM2-Mediated Nrf2 Transactivation and Confers Neuroprotection. Nature Communications, vol

Autophagy 2014

This suggests that this compound, and compounds with similar mechanisms, could represent a promising therapeutic strategy for complex inflammatory conditions like atopic dermatitis, where multiple pathways are involved

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However, interpretation of these signatures may be confounded by kidney function and medication use, and clinical translation will require rigorous external validation, particularly in prospective cohorts and trials specifically designed for DKD