The field is rapidly moving beyond single-target GLP-1 agonism: dual and triple agonists, combining GLP-1 with receptors for GIP and/or glucagon, are designed to produce larger weight loss and beneficial metabolic effects
Using a unique, genetically engineered mouse model, the researchers demonstrated that newer small-molecule GLP-1 drugs such as recently approved oral medications can reach deep regions of the brain
Nutritional ketosis during weight loss is generally mild and not harmful in individuals without diabetes
-------------------------------------------------------------------------------------------------------------------------------------- Regular training, cutting period, or seasonal diet
Many people do best with protein-forward choices, simple planning, and hydration between meals
Pharmacokinetics of NNC0090-2746 showed a C max at 5.4 nM with a single dose of 1.8 mg (106) and C max at 12 nM at the steady state with a daily dose of 2 mg in patients with T2DM (107)