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In an experimental model using a lethal dose of 600 mg/kg APAP in adult wild-type mice, administering a high dose of 300 mg/kg NAC at 1-h post-APAP exposure resulted in significant therapeutic effectiveness, with 100% survival

Depletion of NADPH impairs NO synthesis and lowers glutathione levels, causing an overproduction of oxygen free radicals, which compromises endothelial cell function in blood vessels (Belenichev et al., 2023)

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During the lyophilization (freeze-drying) process, the peptide often forms a solid, compacted puck or disc at the bottom of the vial