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Obesity is associated with an increased risk of at least thirteen cancers and with negative cancer outcomes including increased metastasis, impaired response to therapy, elevated risk of recurrence, and an increase in cancer-related mortality 2,3,4,5

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Body adapts via profound fat and muscle catabolism but maintains serum albumin relatively

Expert Review of Molecular Diagnostics, 19(9), 797-807

Both IDH1 and IDH2 enzymes utilize NADP + as their cofactor and generate NADPH via oxidative decarboxylation of isocitrate outside the context of the TCA cycle

| DOI: 10.1097/WNO.0000000000002431 Copyright 2025 by North American Neuro-Ophthalmology Society