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Individual Metabolic Factors Your baseline metabolic characteristics influence response: Body weight and composition : Higher body weight results in lower drug concentrations at a given dose, potentially affecting response magnitude (though time to steady state remains ~4-5 weeks) Insulin resistance severity : Those with more severe metabolic dysfunction may experience slower glucose improvements Age : Age has no clinically meaningful effect on semaglutide pharmacokinetics [12] [13] Kidney function : No dose adjustment is needed for renal impairment, as it doesn't significantly alter semaglutide pharmacokinetics [1] [3] Lifestyle Factors Semaglutide works most effectively when combined with lifestyle modifications