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The former operates through negative feedback and produces native, binding-protein-regulated IGF-1

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In phase 2b, Lani decreased liver fibrosis and MASH, but led to body weight gain, anaemia and fluid retention (peripheral oedema) 3

172 Genes involved in pathways related to oxidative stress and antioxidant defense might therefore be potential genetic modifiers in AATD-related liver diseases, and warrant further investigation