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It facilitates the availability of fatty acids for muscle tissue and is naturally present in cells that utilize fat for energy
In the context of ER stress, the RIDD pathway plays a cytoprotective role, while IRE1 promotes the production of XBP1s, which in turn promotes the expression of genes beneficial to ER stress recovery (Shishova et al., 2022)
This result may be due to the low percentage of functional thyroid tissue in children with cretinism in which T4 is converted to active T3 at the periphery in the presence of Se supplementation only
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Mechanistic explanations include copper-dependent enzyme cofactor support and signaling-pathway activation