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The brain is classified among the most generating organs for the reactive oxygen species (ROS), where 4% of the oxygen consumed by the mitochondria is converted into super oxide superoxide ion (O2), which possesses exceptionally high reactivity, particularly as a powerful oxidizing agent and an initiator of radical reactions
2016;352:h6234
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Roll the vial gently rather than shaking it, which can damage fragile peptide bonds
Additionally, validation methods such as gene knockout and antagonists are lacking, warranting further evidence to support the specificity of TCM and its targets
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