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1: GIP and GLP-1 receptors in the hypothalamus and brainstem involved in the regulation of energy intake (meal initiation and termination) and body weight

It stimulates the pituitary gland to produce and release GH, akin to CJC-1295 and Ipamorelin but with a slightly different mechanism

Brown HA

Used together, they aim to increase GH in a steady, pulsed pattern

( Glycemic Control Compared to maintaining GLP-1RA, both strategies of adding basal insulin (i.e., free-up titration of basal insulin or switching to FRC) effectively decreased HbA1c from baseline to week 26 (free up-titration, WMD 0.71%, 95% CI 1.05 to 0.37

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