Havrylyuk, A., Chopyak, V., Boyko, Y., Kril, I
In this phase II trial involving 50 men with metastatic castration-resistant prostate cancer (mCRPC), the administration of docetaxel combined with oral curcumin (6 g/day for 7 days every 3 weeks) demonstrated no significant differences in progression-free survival (PFS), PSA response, overall survival, or quality of life (QoL) when compared with placebo, despite high compliance and confirmed curcumin absorption
A conjugation of AITC to glutathione in planta might be non-enzymatic or catalysed by GSTs, as indicated by the AITC-induced upregulation of several GST-encoding genes 17,40,41 and similar to what was recently shown for indol-3-ylmethyl-ITC 35
Low-dose oral minoxidil is the latest off-label option, though it has some question marks surrounding blood
That three-receptor approach is what separates it from Tirzepatide (dual agonist) and Semaglutide (single agonist), and the clinical data reflects that gap clearly
Toxicology 357 , 2132 (2016)