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circRNAs circRNAs possess a closed continuous loop structure, and they are generated primarily from the back-splicing of precursor mRNAs (pre-mRNAs) and rarely from the self-splicing introns of ribosomal RNAs, mitochondrial RNAs and tRNAs

This is a dramatic reduction. The changes in waist circumference paralleled changes in estimated VAT, assessed using DXA scans

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A similar finding was observed in the elevated plus maze (EPM) test (Supplementary Fig

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