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According to one theory, insulin resistance results from the buildup of non-esterified fatty acids (NEFA) in non-adipose tissue organs including the liver and skeletal muscle caused by adipose tissue malfunction, which causes an excess of NEFA in the blood (115) (Figure 2)

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The amount of free radicals produced by our cells becomes consistently higher than normal and overwhelms our glutathione production capacity*.

However, in a study by Arts and colleagues, better symptom control was obtained with short-acting octreotide three times a day than with long-acting octreotide administered monthly 17,28

Estimation of -cell mass by metabolic tests: necessary, but how sufficient