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For instance, PGC1-related coactivators can activate the expression of NRF1, NRF2, and transcription factor A (TFAM, the final effectors of mtDNA transcription and replication) to regulate the expression of respiratory chain and the biogenesis of mitochondria, a process that has been well-documented in previous reviews (Gleyzer et al., 2005

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Another important process underlying ferroptosis depends on the interplay between lipid peroxidation and antioxidant defense mechanisms [2]

Dickens AM, Posti JP, Takala RSK, Ala-Seppl H, Mattila I, Coles JP, et al

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