In June 2021, the FDA approved semaglutide for long-term weight management in adults with obesity or overweight conditions, marking a significant milestone in pharmacological weight loss therapies
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Households with at least one GLP-1 user reduce grocery spending by 5.3% within six months of adoption, with high-income households seeing spending down 8.2%, according to data from Cornell University and Numerator
Formation of hexa- and decadepsipeptides via NRPS misoperation is key to form the isocereulides E, F and G, whereas peptide assembly in the biosynthesis of isocereulides A-D corresponds well to that of cereulide differing that L- O -Val is substituted by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D-O-Leu by D-O-Val (isocereulide B) due to a relaxed substrate specificity of the A domains and/or an inefficient proof reading by CesT
