The one human knee study, Lee et al
doi: 10.3748/wjg.v18.i21.2609
After subcutaneous administration, it circulates systemically, reaches multiple injury locations simultaneously, and modulates the inflammatory environment throughout the body rather than at a single point
It is therefore entirely plausible that chronic saturation of this receptor complex by UMFA could interfere with the reuptake and retention of their respective ligands, including holoTC and vitamin B-12, and this effect could be accentuated in individuals with renal insufficiency
Second, lipogenesis decreases, meaning less dietary energy gets converted to stored fat
That potentially, ingredients that could help clear out, or keep clear, the liver so that it has ROOM to do its job, would then mean it will do a better job