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Cell Physiol Biochem 2016;39:7180

Acipimox may be used instead of nicotinic acid to improve AN while improving lipid profile.[24] TOPICAL TREATMENT Retinoids Topical retinoid is considered first-line treatment, especially for unilateral nevoid AN.[10] It is epidermopoietic and causes a reduction of the stratum corneum replacement time

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Nitric oxide synthesis modulation governs vascular tone and blood flow, directly improving oxygen delivery to damaged tissue across the gut, muscle, and neural systems

PMC 2621289

There isnt enough reliable information available to determine its safety during pregnancy and breastfeeding