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277 ,309 Only the study reported by Sloan et al 309 included a well-accepted scale of health-related quality of life (the Medical Outcomes Study Short Form-36 instrument)

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These defects were accompanied by disrupted phosphorylation of the IRS, as well as down-regulated expression of mitochondrial proteins PPAR co-activator 1 (PGC1) and uncoupling protein-2 (UCP-2) [200]

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