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Email: [email protected] Received: 03 November 2024 / Revised: 04 December 2024 / Accepted: 05 December 2024 / Published: 28 December 2024 DOI: 10.31491/APT.2024.12.158 Abstract Fibrotic disorders, such as idiopathic pulmonary fibrosis, are characterized by the accumulation of myofibroblasts, cells responsible for excessive extracellular matrix deposition and tissue remodeling

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The essential oil from Alpinia zerumbet (EOAZ) has shown effects similar to olanzapine in mitigating schizophrenia-like symptoms induced by repeated ketamine administration, with fewer side effects (de Arajo et al., 2021)

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Abbreviations 2HG: 2-Hydroxyglutaric acid Acetyl-CoA: Acetyl coenzyme A ASS: Argininosuccinate synthetase CAF: Cancer-associated fibroblast ccRCC: Clear cell renal cell carcinoma ECG: Epicatechin gallate EGCG: Epigallocatechin gallate ETC: Electron transport chain FDG-PET: Fluorodeoxyglucose-positron-emission tomography FH: Fumarate hydratase GBM: Glioblastoma multiforme GDH: Glutamate dehydrogenase GLS: Glutaminase GOT: Glutamic-oxaloacetic transaminase GPNA: l--Glutamyl- p -nitroanilide GPT: Glutamic-pyruvate transaminase HIF: Hypoxia-inducible factor IDH: Isocitrate dehydrogenase IDO: Indoleamine-2,3-dioxygenase IL: Interleukin NK: Natural killer (cell) NMR: Nuclear magnetic resonance PEG: Poly(ethylene glycol) PHD: Prolyl 4-hydroxylases PLGA: Poly(lactic-co-glycolic acid) PPP: Pentose phosphate pathway PSAT: Phosphoserine aminotransferase RCC: Renal cell carcinomas SDH: Succinate dehydrogenase SHMT: Serine hydroxymethyltransferase SIRM: Stable isotope-resolved metabolomics TAM: Tumor-associated macrophage TCA: Tricarboxylic acid TDO: Tryptophan-2,3-dioxygenase TGF: Transforming growth factor beta TNBC: Triple-negative breast cancer TNF: Tumor necrosis factor alpha T reg : Regulatory T cell TXNIP: Thioredoxin-interacting protein UTR: Untranslated region -KG: -Ketoglutarate References Chen, J