10.31887/DCNS.2016.18.4/jmarrocco 142
(2009) 297:G34860
Mechanisms of tumor growth inhibition by depletion of -glutamylcyclotransferase (GGCT): a novel molecular target for anticancer therapy
Most notably, insulin-receptor substrate-2 (IRS2) had multiple significantly upregulated phosphosites in CI compared to VI (T517, T524, S556, S573, S616, S907, and S1089) many of them among the topmost upregulated of all 747 phosphosites (e.g., fifth and seventh), an effect not observed with insulin-receptor substrate-1 (IRS1
These findings demonstrated that ZFPG + US treatment effectively augmented the infiltration of CD8 + T cells within the tumor, thereby achieving potent sono-metallo-immunotherapy
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