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Patients who underwent randomization were treated with at least one dose of study medication, and had available post-baseline data on exacerbation were included in the FAS for exacerbation, and those who had available spirometry data at 12 months or 24 months were included in the FAS for lung function

Approximately one-half of individuals in these trials did not have diabetes

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The energy minimization and molecular dynamics simulation were done for the optimization of the models and monitoring their structural fluctuations

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