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Preliminary research also shows that pairing vitamin B12 supplementation with antidepressants could help significantly reduce symptoms of major depressive disorder to a greater extent than treatment with an antidepressant alone

The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN

How Often Should You Get B12 Shots vs IV Infusions

PMID: 26277634 16 Recognizing Subacute Combined Degeneration in Patients With Normal Vitamin B12 Levels

When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair

Some start with more frequent visits and then shift to monthly maintenance