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Although GIP receptor activation may exert anti-emetic effects through brainstem modulation, these effects appear insufficient to completely counterbalance GLP-1 mediated emesis during early treatment and dose escalation ( In contrast, glucagon receptor activation is independently associated with nausea and vomiting through both central and peripheral mechanisms, including effects on gastric motility and autonomic signaling

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Children of 5 years who weigh 50 lbs, the recommended dose should not exceed 75-100mg (1.5 to 2mg/lb)

Plant melanin is insoluble in pure water, while alkaline solutions are not good for food applications, especially in the presence of oils, where they could cause saponification reactions

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