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Drugs Today (Barc) 54:713719

For decades, scientists and futurists alike have pointed to 120 years as the upper limit of human lifespan

Depletion of glutathione and upregulation of GPX4 peroxidase activity in response to oxidative stress may further drive the production of neuromelanin and inhibit reduction of lipids [5]

(2) depleted hepatic glutathione levels and its intermediates despite unchanged level of reactive oxygen species, suggesting glutathione consumption exceeds production due to systemic oxidative stress after AKI

Culotta, Johns Hopkins University, Baltimore