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It was initially developed for its potential to aid in fat loss and is often marketed as a fat-burning peptide that can help people lose weight without the side effects typically associated with HGH
Sequences which could not be unambiguously assigned to a genus were labeled unclassified (Fig
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Lipotropic injections carry additional risks due to unregulated formulations, including variable ingredient quality, infection risk, and potential allergic reactions to multiple components
The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly