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Because correlation is not causation

FEBS J 283:22192232 Sancho P, Mainez J, Crosas-Molist E, Roncero C, Fernandez-Rodriguez CM, Pinedo F, Huber H, Eferl R, Mikulits W, Fabregat I (2012) NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development

It is commonly seen in females and has two typesautomatic or focused

This creates positive pressure inside the vial, which sounds helpful

This means your refrigerator, not your freezer, not your counter, not a cool dark cabinet

In addition, they are also the main source of ROS based on electron leakage from the respiratory chain (Scial et al., 2017)