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Your clinician will manage titrationslowly adjusting your medication to find the right doseand provide practical strategies to prevent or manage side effects

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Among the companies that took up the gauntlet was Novo Nordisk, a Danish company which grew out of one founded in 1923 to produce insulin (figure 36)

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Stimulation of GLP-1R with exendin-4 in the PBN reduces food intake and therefore decreases body weight in rats

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For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period

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