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Clinical signs Early clinical signs are usually unspecific such as intermittent appetite, weight loss, polyuria/ polydipsia, occasional vomiting or diarrhea and lethargy

Endocrinopathies (such as ICI-induced hypothyroidism and diabetes) and rheumatological toxicities (such as arthritis) are the most common chronic irAEs (48, 49)

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As more women explore alternatives to hormone therapy, we offer a new horizon for managing not only hot flashes but the broader health challenges that often accompany menopause

A Greek-yogurt breakfast plus a gummy often keeps users full until lunch, trimming the 10 a.m