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These SOD convert superoxide to peroxide and thereby minimize production of the hydroxy radical, the most potent of the oxygen free radicals
( c-e ) Immunoblot of the indicated proteins in cells treated with the IDH1 inhibitor ( c ), cultured under glutamine starvation (GS) ( d ), or supplemented with succinate ( e ) and supplemented with KG, propionylcarnitine (Prop-Carn), or butyrylcarnitine (But-Carn)
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In randomized clinical trials in adult patients, cholelithiasis was reported by 1.6% of WEGOVY-treated patients and 0.7% of placebo-treated patients