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Inhibition of phospholipase D 1/2 (PLD1/2) blocks ROS accumulation, iron metabolic disorders, and NLRP3 activation simultaneously, indicating that both processes share upstream regulatory nodes controlled by the PLD signaling pathway

The NFS1 cysteine desulfurase can promote ironsulfur cluster biosynthesis

Provenance and peer review: Invited article

This is why these medications carry a black box warning for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2