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In lung cancer models, lutein was found to induce apoptosis by modulating PI3K/Akt signaling, effectively inhibiting Akt to trigger cancer cell death while sparing normal cells ( 3.2.4 Carotenoids: oxidative stress and miRNA networks Lycopene modulates oxidative stress-responsive miRNAs in prostate cancer through antioxidant pathways

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C.et al (2015)