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Consistent with this TFEB-dependent remodeling of the endolysosomal system, zinc also induces the expression of lysosomal proteases, including cathepsins B and D, thereby enhancing lysosomal proteolytic capacity 103

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Also, the production of E-selectin, ICAM-1, IL-8, and MCP-1, evaluated in the cell culture supernatants, as well as the generation of ROS and malondialdehyde, in HUVECs, significantly increased with arsenic treatment [188]

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Unknown Risks: Given its influence on fundamental metabolic processes (AMPK) and mTOR regulation, the long-term safety of chronic, supraphysiological MOTS-c administration is unknown and requires caution