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RNA-seq and subsequent gene set enrichment analysis (GSEA) revealed that the liver tissue from Gclc KO mice was enriched in several gene signatures associated with stress responses, including those related to the activation of NRF2 (Fig

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This gene is located on chromosome 2q37.3 and is responsible for encoding D-2-hydroxyglutarate dehydrogenase, whose primary function is to convert D-2-hydroxyglutarate (D-2-HG) into -ketoglutarate [53]