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The most significant and cumulative weight reduction generally occurs between months three and twelve, with continued progressive results through 68 weeks (and beyond) in clinical trial data

Isnt the real question we should be asking is do we have chronic deficiencies because of this

Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

2019;171:ITC8196

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These metabolites, which exhibited hub-like behavior at baseline, showed comparatively lower connectivity following the dietary intervention, suggesting a modulation of pathway-level interactions rather than complete network reorganization