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This receptor was originally identified as R eceptor for A dvanced G lycation E nd-products (RAGE)

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Probiotics ( Lactobacillus Kruis plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related gene expression, gut microbiota, and metabolic pathways in mice

2008;121:S815

This modification causes the reduced binding affinity to insulin-like growth factor binding proteins (IGFBPs)

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