Earlier this year, the pharma company confirmed that its GLP-1 focused drug, currently just called PF-08653944, is performing very well in Phase 2b trials
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( D ) Glycolysis was measured as the ECAR in caSMCs treated with MTP siRNA (gray bars) or control siRNA (white bars) and pretreated with 100 nM GLP-1(2836) or scrambled control ( n = 3/treatment, each in triplicate)
Preclinical studies have demonstrated that GLP-1 signalling can modulate inflammatory pathways