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Solvent A was prepared by mixing 99 mL of Milli-Q (Millipore) water and 1 mL of 1 mol/L ammonium bicarbonate and was adjusted to a pH of 9.2 with 25% ammonium hydroxide (~0.1 mL)

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Retatrutide is in Phase 3 clinical trials through Eli Lilly, and cagrilintide is in Phase 3 trials through Novo Nordisk (both as monotherapy and as part of CagriSema)

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