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Prolonged IGF-1 elevation may interfere with insulin signaling pathways, resulting in glucose metabolism disruption and increased diabetes risk. Clemmons, The Journal of Clinical Endocrinology & Metabolism Cell Overproliferation and Cancer Concerns IGF-1 promotes cell growth and replication , which is great for musclebut not ideal in individuals with: A history of cancer A family history of hormone-sensitive tumors Undiagnosed growths or cysts IGF-1 is considered mitogenic , meaning it encourages cell division

Elevated glucose levels activate the enzyme aldose reductase (AR), which transforms glucose to sorbitol, with NADPH serving as a coenzyme for this process

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Cancer Cell 23:739752 Li AM, Ye J (2024) Deciphering the Warburg effect: metabolic reprogramming, epigenetic remodeling, and cell dedifferentiation

Sequential changes in the signal transduction responses of skeletal muscle following food deprivation

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