Another potential plus: price
Drugs with wide therapeutic indices (metformin, most antihypertensives) tolerate the change
Furthermore, in bile ductcannulated (BDC) rats, the average recovery rates of total radioactivity in bile, urine, feces, and cage cleaning fluid collected during 72 h after dosing were 9.08% 0.86%, 17.77% 6.35%, 2.73% 0.40%, and 0.91% 0.13%, respectively (Table 8
We know from bariatric surgery data that significant weight loss and altered nutrition absorption can be associated with lower bone density and osteoporosis, says Marilyn Tan, MD, an associate professor of medicine and endocrinologist at Stanford Health Care in California, who was not involved in the study
Estey E, Pierce S, Kantarjian H, O'Brien S, Beran M, Andreeff M , Escudier S, Koller C, Kornblau S, Robertson L
This histopathological analysis is in agreement with the observed result in the MDA, a biochemical indicator of necrosis