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The human evidence is limited, but the mechanistic rationale is enough that this remains an active research area

For the complex relationship between TMAO and its metabolic precursors and chronic cardiovascular disease, more rigorous experimental protocols need should be designed to eliminate the interference of different precursor metabolites

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Change history 03 October 2017 A correction has been published and is appended to both the HTML and PDF versions of this paper

Without maintenance and strict sun protection, the body will eventually return to its baseline melanin production levels