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Effects of tirzepatide, a dual GIP and GLP-1 RA, on lipid and metabolite profiles in subjects with type 2 diabetes

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doi 10.1093/ecco-jcc/jjaf167 104 BergenholtzSGoldSSpencerEAFreidHMarionJFWongS-Y

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GLP-1 and GIP receptors are expressed in regions including the hypothalamus, hindbrain, and area postrema, and tirzepatide is used as a tool compound to probe how dual receptor engagement modulates neuronal firing, appetite-related gene expression, and neuroinflammation markers in cell and organoid systems

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