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For instance, in the administration criteria of Canadian Drug Expert Committee for semaglutide in patients having type-2 diabetes, it states that the medication should only be prescribed, in combination with MET or Metformin alone, when exercise and diet along with maximal tolerated dose of MET is not able to achieve optimal glycemic control

Dose reduction, slower titration, or treatment discontinuation may be appropriate depending on symptom severity and individual risk-benefit analysis

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An increased dosage will cost more