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Research suggests that GLP-1 RAs, while inducing overall weight loss, generally preserve lean mass to a greater extent than traditional calorie-restriction strategies

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Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size

doi: 10.2165/11630900-000000000-00000

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