A probiotic, at best, supports the gut's own signaling inputs
Braz J Cardiovasc Surg 33:129134
AMPK is thought to be a tumor suppressor, too, essentially starving cells while they attempt to form cancerous tumors (though after cancer has developed, AMPK can sometimes promote tumor growth instead).14 As an antimicrobial agent We know that berberine has long been used as an antimicrobial agent in traditional Chinese medicine, and it remains a treatment for diarrhea from both bacterial infections and noninfectious conditions.16 (Ironically, diarrhea and stomach pain are sometimes side effects when you start taking berberine.)
doi: 10.12659/AJCR.925020 279 TownsendD
(2008) showed that, in fasted rats, an elevated ghrelin tone was associated with an increased activation of hypothalamic AMPK and a decreased mRNA expression of enzymes (like FAS) involved in the de novo fatty acid biosynthesis only in the VMH
If the zinc oxide is going to block copper, it might also block skin rejuvenation