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Clinical trials show that participants taking higher maintenance dosesparticularly the maximum tolerated levelachieved weight reductions of 20% or more of body weight

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The important point is that, these influences can be free of alterations in the substance of -handling proteins (73)

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Current therapeutic strategies focus on blocking EV production/uptake [53] , intercepting EV-activated pathways (MEK/ERK, TGF) [56] , and disrupting EV-mediated microenvironmental reprogramming [57]