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It serves as a key substrate for several enzyme families that keep cells healthy: Sirtuins (SIRTs) NAD+-dependent deacetylases that regulate metabolism, DNA repair, and stress responses Poly(ADP-ribose) polymerases (PARPs) Enzymes that detect and repair DNA damage CD38 and other NADases Proteins that consume NAD+ and regulate calcium signaling These enzymes need NAD+ to work properly, which creates a direct connection between NAD+ levels and overall health

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They recommend that mothers and doctors weigh the benefits of the drug against the potential risks to the baby

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[DOI] [PubMed] [Google Scholar] 477.Morabito R, Remigante A, Di Pietro ML, Giannetto A, La Spada G, Marino A

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