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Based on the conducted studies, general conclusions can be drawn that semaglutide has a predictable pharmacokinetic profile with a long t1/2, allowing for once-weekly subcutaneous administration

However, it suggested that a ureido residue with its side chain shifted to the second backbone methylene (i.e

The most commonly reported adverse effects were mild to moderate headache and gastrointestinal symptoms including diarrhea, flatulence, nausea, and increased appetite

7F, G) and EE (Fig

Diabetes-related thrombotic risk factors include: Hyperglycaemia-induced endothelial dysfunction , promoting a prothrombotic state Increased platelet reactivity and aggregation Elevated levels of clotting factors including fibrinogen and von Willebrand factor Chronic inflammation with raised inflammatory markers Impaired fibrinolysis , reducing the body's ability to break down clots Obesity independently increases thrombotic risk through multiple mechanisms

Descriptive statistics were expressed as number and percentage for categorical variables and as mean(SD) for numerical variables