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DPP-4 is a potent lyase of substance P and DPP-4i prevents the degradation of substance P from an activated state to an inactivated state

You might also see a slight increase in body weight within the first week or two due to water retention in your muscles

Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY

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At 16-weeks follow-up visit, the patient presented for clinical evaluation, and she had an acceptable salivary flow with modified Schirmer test showing 27 mL at 3 minutes