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The class of medications called glucagon-like peptide-1 receptor agonists (GLP-1RAs) was first authorized in the early 2000s and includes semaglutide, which gained Food and Drug Administration (FDA) approval in 2017 for patients with Type 2 diabetes

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Knee pain, measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), improved by up to 4.5 points, representing a 75.8% reduction from baseline

doi: 10.7150/ijbs.59965 119 HamalSCherukuriLShaikhKKinningerADoshiJBirudarajuDet al