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Side Effects Both medications can cause: Nausea Constipation Reflux Fatigue in the beginning Tirzepatide may cause a bit more nausea for some people, but it also seems to be better tolerated in others

The triple mechanism suggests that discontinuation effects could be even more pronounced than with tirzepatide

Each additional compound introduces its own side effect profile, interaction potential, and pharmacokinetic considerations

The point is to use medication intelligently

Yes, certain dietary strategies may enhance natural GLP-1 secretion, including consuming adequate fiber (25g for women, 38g for men daily), incorporating healthy fats, and eating sufficient protein

PMCID: PMC7084196